9-Benzoyl 9-deazaguanines as potent xanthine oxidase inhibitors
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چکیده
منابع مشابه
Structure-Activity Relationship of Xanthones as Inhibitors of Xanthine Oxidase.
Polygala plants contain a large number of xanthones with good physiological activities. In our previous work, 18 xanthones were isolated from Polygala crotalarioides. Extented study of the chemical composition of the other species Polygala sibirica led to the separation of two new xanthones-3-hydroxy-1,2,6,7,8-pentamethoxy xanthone (A) and 6-O-β-d-glucopyranosyl-1,7-dimethoxy xanthone (C)-toget...
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The discovery of the stimulation of cell division in plant tissues by trace amounts of kinetin, 6(2-furfuryl) aminopurine (11), has resulted in a number of investigations concerned with the effects of this and related compounds on a variety of plant and animal systems (4, 5, 7,9, 10, 12, 13). One system, developed for study of the in situ effect of agents upon the maintenance of normal organiza...
متن کاملPyrazolopyrimidines as inhibitors and substrates of xanthine oxidase.
A variety of purine and azapurine analogues have been shown to serve as substrates for and inhibitors of xanthine oxidase. Thus, in addition to its usual substrates, hypoxanthine and xanthine, and its demonstrated activity on certain pterines (I), pyrimidines (2)) and aldehydes (3), the following purine analogues are oxidized by xanthine oxidase: adenine (4), 2-azaadenine (5), 6-mercaptopurine ...
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A new group of compounds analogous to the purines was recently described (1) in which carbon atom 2 of the purine ring was replaced by nitrogen. One of these imidazo-1 ,2,3-triazines (I), conveniently called 2-azaadenine, was shown to be an antagonist of hypoxanthine and of adenine in its toxic action against bacteria and mice. The corresponding hydroxy compound, 2-azahypoxanthine, was relative...
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Increased uric acid levels are correlated with cardiovascular disease, particularly with ischaemic heart disease. Xanthine oxidase inhibitors, especially allopurinol, lower the risk of ischaemic heart disease due to their effects on reactive oxygen species and endothelial function. In chronic stable angina pectoris, allopurinol increases the median time to ST depression, time to chest pain, and...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry
سال: 2016
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2015.12.006